Formulation and Evaluation of Antioxidant Activity from Ziziphus mauritiana Lam Gel Extract

Abstract

Ziziphus mauritiana Lam or bidara contains phenolics and flavonoids which have antioxidant properties. This study aims to formulate bidara leaf ethanol extract in gel dosage form and test for its antioxidant activity. The gel base is made with variations in the concentration of HPMC 3%, 5%, and 7%. Then the gel stability was evaluated for 3 weeks. Antioxidant activity was tested by the DPPH method. Ethanol extract of bidara leaves can be formulated into antioxidant gel preparations with a variation of 3% and 5% HPMC bases, where the gel has good physical properties and stability, as evidenced by the absence of organoleptic changes, pH, viscosity, and dispersal during evaluation. Antioxidant activity of bidara leaf ethanol extract gel has different antioxidant activity based on variations in HPMC concentration. Formula 1 has moderate antioxidant activity with percent inhibition of 52.55%.