Formulation and Evaluation of Anti-diabetic Herbal Tablet containing Syzygium cuminii, Swertia chirata and Gymnema sylvestre

Abstract

In a developing nation like India, diabetes has imposed an immense burden on the health care system. There is additionally an alpha-amylase of blood sugar levels in diabetes patients in the numerous treatment approaches. Therefore, it is unquestionably crucial to scientifically screen medicinal plants for their use in treatments to ensure that they are both safe and effective. Our present research investigates the alpha-amylase inhibitory action of methanolic extracts from the Syzygium cuminii seeds, Gymnema sylvestre leaves, and Swertia chirata leaves three indigenous medicinal herbs. With the use of the alpha-amylase model and the 3, 5-dinitro salicylic acid (DNSA) approach, the anti-diabetic action was carried out. The fundamental concept of the DNSA approach is the color-change principle, which is further validated by the colorimeter. The findings demonstrated that the alpha-amylase inhibitory action is present in all three methanolic extracts of Syzygium cuminii seeds, Gymnema sylvestre leaves, and Swertia chirata leaves. Furthermore, we concluded that Syzygium cuminii seed extract is more effective than the other two at inhibiting alpha-amylase activity. Based on the findings of this study, we endorse the use of all three methanolic extracts in the management of diabetes mellitus.