Abstract
Abstract: Acne vulgaris is a long-term inflammatory disorder of the pilosebaceous unit that leads to the formation of inflammatory lesions, seborrhea(Scaly red skin), comedones(Blackheads and whiteheads), Papules(Pinheads), Nodules(Large papules) etc. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as performing bacteria triggering inflammation in acne. Bacilis subtilis support to cause inflammation in acne. Natural remedies are more acceptable in the belief that they are suffering from fewer side effects than synthetic ones. Herbal formulations have a growing demand in the global market. This present research work aims to formulate and evaluate herbal antiacne gel containing ethanolic extract of Neem (Azadirachta indica), Garlic(Allium Sativum). The herbal antiacne gel was optimized by preparing 1 formulations (F1) using an extract of Neem, Garlic a combination of these two extracts. The formulation was evaluated for various parameters like Physical appearance, pH, Drug content, Spreadability, Extrudability, and Anti-acne activity assay against Bacilis subtilis. Amongst all the formulations studied, batch F3 was found optimum for all the parameters. all extracts i.e. ethanolic extract of Azadirachta indica, Allium Sativum in combination show potential effect against Acne vulgaris and also exert a synergistic effect on the bacteria
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