Formulation and Evaluation of Aceclofenac Liposomes

Abstract

Patients who suffered from rheumatic disease and osteoarthritis are generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Osteoarthritis is a common musculoskeletal disorder, which impairs body function and acts as an economic burden. Due to the repetitive use of ACE by oral route, it may cause gastrointestinal complications such as ulceration, bleeding, pain, perforation. To decrease the side effects of ACE, it is given by topical route in the form of ointment. This review highlights reducing gastrointestinal problems and promotes the safety and efficacy of the ACE. The Aceclofenac liposomes were prepared by the thin film hydration technique and evaluated by various methods such as in- vitro release study, % yield, drug entrapment efficiency, pH of the prepared formulation. The prepared system was also characterized by Fourier transform infra-red spectrophotometer to identify the drug- excipients interaction. The maximum entrapment efficiency of liposomes was found to be 90%. The main aim of this study was to develop and characterized a vesicular drug carrier system for topical delivery of Aceclofenac to overcome the problem related with oral route.
 Keywords: Liposomes, Aceclofenac, topical delivery, transdermal delivery, rheumatic disease and osteoarthritis