Abstract
Formulation and evaluation of a solid self-emulsifying drug delivery system containing cefuroxime axetil
Highlights
One of the biggest problems in formulation of oral pharmaceutical dosage forms is the lipophilic nature of the drug substances, various formulation strategies have been explored in recent years such as usage of lipid solutions, emulsions and emulsion concentrates prepared as physically stable formulations suitable for encapsulation of poorly soluble drugs (Rodriguez-Aller et al, 2015)
Various formulation strategies have been used for solidification of selfemulsifying drug delivery systems (SEDDS), among which the simplest approach is adsorption of the SEDDS to solid carriers–excipients, commonly used in tablet formulation (Mandić et al, 2017)
Determined CA content and the drug release studies from different tablets as solid SEDDS formulations showed that sample S3 released ~ 87% of CA during the period of 15 min. and more that 96% after 45 min. (99.6% CA content), complying with the USP specification for conventional CA tablets
Summary
Soft gelatine capsules are simple and commonly used dosage forms for encapsulation of liquid SEDDS, this technology have some limitations i.e. manufacturing and packaging process difficulties, stability of the final drug product, etc. Due to these reasons, attention has been focused on formulation of solid SEDDS in form of tablets (uncoated or film-coated tablets) (Joyce et al, 2018).
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