Formulation and Development of Extended Release Matrix Tablet of Carvedilol Phosphate

Abstract

Carvedilol Phosphate, a non selective β-blocker drug under BCS class П and used in treatment of Hypertension. Solubility of the drug and its bioavailability is low. The purpose of the present study is to design extended release matrix tablet of Carvedilol Phosphate to improve gastric retention and reduce gastric emptying time. All blended formulations were evaluated for bulk density, tapped density, Carr’s index, angle of repose and the Hausner’s ratio. All these results indicated that, the powder blend showed good flow properties. All tablet formulations were evaluated for weight variation, hardness, Friability, Thickness, Content uniformity, In-vitro drug release. Regulated drug release in zero-order manner attained in the current study indicates that the optimized extended release tablet of Carvedilol Phosphate, prepared using Sodium carboxymethyl cellulose and HPMC K4M can successfully be employed in oral controlled release drug delivery system. Modified release ability of the formulation is likely to increase its GI residence time, and eventually, improve the extent of bioavailability.