Abstract
Formulation and Comparative Characterization of Methylcellulose, Carbomer and Petrolatum Gels for Topical and Transdermal Delivery of Zosyn (Piperacillin/Tazobactam) Antibiotics
Highlights
The results showed that the gel with 10% drug loaded Methylcellulose formulation was more stable at temperatures studied and less susceptible to chemical degradation for all the chemicals used
Piperacillin/Tazobactam commonly known as Zosyn is a broad-spectrum combination antibiotic used to treat severe infections
It combines the high antibiotic activity of piperacillin with β-lactamase inhibitor properties of Tazobactam that helps to maintain the susceptibility of bacteria to the antibiotic and prevents resistance
Summary
Piperacillin/Tazobactam commonly known as Zosyn is a broad-spectrum combination antibiotic used to treat severe infections. It combines the high antibiotic activity of piperacillin with β-lactamase inhibitor properties of Tazobactam that helps to maintain the susceptibility of bacteria to the antibiotic and prevents resistance. With the advent of increasing drug resistance to most antibiotics, this combination is an example of successful strategy to fight the menace. It is bactericidal against numerous organisms including gram positive, gram negative, aerobic, and anaerobic microbes [2]. It is used as an off-label antibiotic for uncomplicated intra-abdominal infections, urinary tract infections, bone and joint infections, septicemia, endocarditis, cystic fibrosis exacerbations, and surgical prophylaxis
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