Abstract
Objective: Formulation of Singawalang leaves extract should be considered because the extract contains a variety of compounds so that there maybe a competitor in the absorption process and will cause the absorption of active ingredients in the gastrointestinal decline. One way to increase theabsorption and disposition of active ingredients on target organs is to use a nanoparticle formulation. Therefore, this study will conduct research onself-nanoemulsifying drug delivery system (SNEDDS) formulation of Singawalang (Petiveria alliacea) leaves extract.Methods: The systems were developed by investigating the solubility Singawalang leaves extract in various carrier oil, the suitable surfactant,and cosurfactant, construction of SNEDDS of Singawalang leaves extract and characterization of droplet size through particle size analyzer andtransmission electron microscopy.Results: The results of this study indicate that the optimum carrier oils for Singawalang leave extract are miglitol and virgin coconut oil (VCO),the compatible surfactant component is tween 80 and the compatible cosurfactant is propylene glycol (PG). The average droplet size is 13 nm andpolydisperse index 0,004 and 0,006.Conclusion: It can be concluded, the present study demonstrated that the optimum SNEDDS formulations of Singawalang leave extract are themixture of VCO, tween 80, PG at ratio 1:8:1 and miglitol, tween 80, and PG at ratio 2:5:3.
Highlights
Singawalang (Petiveria alliacea) is a plant widely found in Indonesia and empirically used by residents to treat various diseases such as diabetes and bleeding cough and is used to protect plants from pests
Materials P. alliacea leaves were collected from Balai Materia Medika (BMM) Batu, East Java, Indonesia and were determined by BMM
Selection of self-nanoemulsifying drug delivery system (SNEDDS) components The result showed that Singawalang leaves extract dissolved on virgin coconut oil (VCO), miglitol, and corn oil (Table 1)
Summary
Singawalang (Petiveria alliacea) is a plant widely found in Indonesia and empirically used by residents to treat various diseases such as diabetes and bleeding cough and is used to protect plants from pests. The ethanol extract of Singawalang leaves has the ability to lower blood sugar levels [1,2]. 2015, showed that extract of Singawalang leaves decreased blood sugar level in the mouse model of type 2 diabetes mellitus (T2DM) with the optimum dosage of 360 mg/kg BW and increased 5’ adenosine monophosphateactivated protein kinase expression on liver [3]. This phenomenon raises the hope that the extract can be used as a phytopharmaca drug in the management of T2DM.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
