Abstract
The Skin is one of the most extensive organs of the human body. This multilayered organ receives approximately one-third of all blood circulating through body. With a thickness of about a millimeter, the skin separates the underlying blood circulation network from the outside environment1.
 Transdermal delivery of drugs through the skin to the systemic circulation provides a convenient route of administration for a variety of clinical indications. Transdermal delivery systems are currently available containing scopolamine (hyoscine) for motion sickness, clonidine and nitroglycerin for cardiovascular disease, fentanyl for chronic pain, nicotine to aid smoking cessation2.
 Drug molecules in contact with the skin surface can penetrate by three potential pathways: through the sweat ducts, via the hair follicles and sebaceous glands (collectively called the shunt or appendageal route), or directly across the stratum corneum3.
 
 All transdermal drug delivery systems consist mainly of:
 
 Polymer matrix
 Drug
 Enhancers and other excipients
 
 Other excipient
Highlights
The Skin is one of the most extensive organs of the human body
Drug levels can be maintained in the systemic circulation, within the therapeutic window, for prolong period of time
Controlled and Novel drug delivery CBS Publisher and distributor, 1 st ed., 100-126
Summary
The Skin is one of the most extensive organs of the human body. This multilayered organ receives approximately one-third of all blood circulating through body. With a thickness of about a millimeter, the skin separates the underlying blood circulation network from the outside environment[1]. Transdermal delivery of drugs through the skin to the systemic circulation provides a convenient route of administration for a variety of clinical indications. Drug molecules in contact with the skin surface can penetrate by three potential pathways: through the sweat ducts, via the hair follicles and sebaceous glands (collectively called the shunt or appendageal route), or directly across the stratum corneum[3] All transdermal drug delivery systems consist mainly of Polymer matrix Drug Enhancers and other excipients Other excipient
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical and Biomedical Studies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
