Abstract
The aim of this study was to prepare w/o Micro-emulsions of naproxen for topical application & evaluate in vitro permeation of Naproxen. On the basis of ternary phase diagram and drug solubility test Tween-20, Oleic acid and Polyethylene Glycol 400 was selected and these are eminently used as an appropriate transporting system for introducing Naproxen for transdermal drug delivery. The physicochemical properties of microemulsions such as conductivity, droplet size, viscosity and pH were measured. The in vitro permeability of Naproxen compared with commercial and microemulsions. The permeation rates of Naproxen from micro-emulsions were higher (1.2 times) than marketed gel formulation. Finally, according the histological examination of microemulsions did not show irritant effect on treated skin. In conclusion, the results of this study indicated that the microemulsions especially F5 formulation can be considered as potentially useful vehicles for topical application.
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