FORMULATION AND CHARACTERIZATION OF TABLETS FROM SIMPLICIA AND EXTRACT OF SUNGKAI’S (Peronema canescens Jack) LEAF

Abstract

Tablets are solid preparations containing medicinal ingredients with or without excipients, usually consisting of one or more active substances. Preparations in tablet form have the best mechanical, chemical, and microbiological stability compared to liquid dosage forms, so they are more resistant to physical damage. This study aims to formulation and characterization of tablet from simplicia and dried extract of sungkai’s (Peronema canescens Jack) leaf by wet granulation which consisted of three formulas, namely F1 without active substances, F2 active substances from sungkai’s leaf simplicia, and F3 active ingredients from dry extracts of sungkai’s leaf. The characterization of the physical properties of tablets includes size uniformity test, weight uniformity test, hardness test, friability test, and disintegration test. The results showed that F1 and F3 tablets showed a good tablet properties, but F2 tablets had 3 tablets that deviated from the tablet weight, namely 12.18%, 6.03% and 9.75%, F2 tablets had an average hardness of 3,413 kg. ie does not fullfill the requirements for tablet hardnes. The friability test for F2 tablets, which is 1.0069%, not accetable for tablet friability. The disintegration test, F2 tablets have a faster disintegration time compared to F1 and F3 tablets.