Abstract
Objective: The present research work was to develop and evaluate alprazolam sustained release tablet using Mardi gum, a comparative study on binding properties of gum and hydroxypropyl methylcellulose (HPMC) was performed.
 Methods: Formulation of alprazolam tablets (f1–f6) was done by direct compression method using 15%, 30%, and 45% concentration of gum as a natural binder, and HPMC was used as synthetic matrix forming agent. Microcrystalline cellulose was used as diluents, talc, and magnesium stearate as a lubricant and PVP K30 as the binder. The formulated batches were evaluated for parameters such as tablet thickness, % friability, hardness, weight variation, and in vitro drug release characteristics. The release information was fitted into different dynamics models to decide the release mechanism of the drug.
 Results: The results showed that all the parameters of the developed tablets (f1–f6) were in fulfillment with pharmacopeia limits. In vitro, drug release studies showed that formulation f1 had most controlled and sustained manner releaser with maximum drug release of 97.89±0.52% in 18 h with comparison to f2–f4 and f6 drug release is 98.12±0.55%, 97.24±0.57%, 98.16±0.74%, and 97.26±0.35%, respectively, in 16 h and f5 giving 97.89±0.85% release in 14 h.
 Conclusion: On the basis of obtained result, it can be concluded that Mardi gum can be used to sustain the drug release as a natural polymer in tablet dosage form.
Highlights
Sustained release delivery system is increasingly being used in the treatment of acute and chronic diseases as they maintain the concentration of drug in plasma above the minimum effective concentration to and below the minimum toxic level for an extended period of time [1,2]
Characterization of drug and excipients To determine possible interaction between the alprazolam drug, Mardi gum, and other excipients used in the formulation, compatibility studies were conducted using FTIR spectroscopy
Pre-compression parameters Powder blend prepared for compression of sustained release tablets of alprazolam was evaluated for their flow properties such as the angle of repose, loose bulk density, tapped bulk density, and compressibility index
Summary
Sustained release delivery system is increasingly being used in the treatment of acute and chronic diseases as they maintain the concentration of drug in plasma above the minimum effective concentration to and below the minimum toxic level for an extended period of time [1,2]. The development of sustained release drug delivery systems has broad been a major area of research in the pharmaceutical industry. In the present study, sustained release tablets of alprazolam using exudates from the tree of Terminalia tomentosa were prepared to see its application as a release retardant. Sustained release tablets were prepared using natural gum Mardi and synthetic polymer hydroxypropyl methylcellulose (HPMC) by employing a direct compression method. The objective of the work was to explore a novel natural binding agent and to formulate sustained released tablets of alprazolam so as to reduce its frequent administration and to improve patient compliance. The novelty of the proposed work is the use of Mardi gum as the matrix forming agent to delay the release of the drug
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