Abstract
Formulation and Characterization of Proniosomal Gels loaded with Levofloxacin for dermal drug Delivery.
Highlights
Levofloxacin is a member of the third generation of fluoroquinolones with a potent antibacterial effect and broad-spectrum activity against a wide range of bacterial strains
Preparation of levofloxacin loaded proniosomal gels. Several surfactants such as spans and tweens were screened to choose a convenient surfactant for producing gel formulations
Using the coacervation phase separation method, proniosomal gels were prepared with different nonionic surfactants, including spans and tweens, combined with cholesterol and lecithin measured in determining amounts
Summary
Levofloxacin is a member of the third generation of fluoroquinolones with a potent antibacterial effect and broad-spectrum activity against a wide range of bacterial strains. Levofloxacin is a chiral fluorinated carboxyquinoline, which is the L isomer of ofloxacin. It exerts its antibacterial effect by inhibiting DNA GYRASE and DNA IV topoisomerase resulting in a lethal effect for the cells. Levofloxacin is the drug of choice for treating many complicated infectious diseases. It can effectively treat respiratory tract infections, such as acute sinusitis, acute bronchitis, and pneumonia. It can be used effectively to treat complicated urinary tract infections caused by resistant strains It is an interesting candidate for the treatment of human infectious diseases, but it has several adverse effects when taken orally. Through dermal delivery of levofloxacin, both GI and CNS side effects can be eliminated, decreasing the dose required at the same time [1, 2, 3]
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