Abstract
Aim: The main object of this research work was the development and evaluation of olmesartan medoxomil nanoparticle for the solubility and bioavailability improvement. It is practically insoluble in water (class II, according to BCS). This work aims to improve the olmesartan medoxomil solubility as well as dissolution rate. Materials and methods: For the synthesis solvent evaporation technique was used, and many different types of stabilizers that used (PVP K30, poloxamer 188, HPMC E5, Soluplus, tween 80) in different ratio. Results: The particle size analysis indicated that the optimized formula 7 had a reduced nanoparticulate size of 86.38 nm, with more than 90 percent increase in in-vitro dissolution profile compared to 17 percent for the comparison olmesartan medoxomil powder in phosphate buffer PH 6.8. Conclusion: nanoparticle formulation of weakly water soluble olmesartan medoxomil greatly improved the drug's dissolving rate and increased its solubility.
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