Abstract
Diclofenac Sodium is a non-steroidal anti-inflammatory drug (NSAID), which has analgesic, anti-inflammatory, and antipyretic effects. Diclofenac sodium topically (gel 1%) has mild site reactions, with a relatively short duration of action and low permeability need for multiple uses. This study aimed to produce hydrogel of proniosomes to enhancing solubility and permeation of diclofenac topical used. Proniosome was prepared by using the coacervation phase separation method using Span 60 and Tween 80, lecithin and cholesterol. The hydrogel base was prepared from carbopol 940, then Proniosome was mixed in ratio one to one (1:1). Viscosity, release, permeation and stability were assayed. Results revealed a successfully prepared hydrogel loaded with proniosomes, which was consequently loaded with its payload. The release study carried out in vitro revealed a control-released behaviour over 28 hours which was 6 fold higher than the ordinary preparation i.e. lack of proniosomes. To sum up, the hydrogel of Proniosome preparation loading with Diclofenac Sodium was approved to overcome controlled release and skin permeation problems.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.