FORMULATION AND CHARACTERIZATION OF HERBAL TABLETS FOR THE MANAGEMENT OF DENGUE

Abstract

Tablets are used as formulation and are prepared by using plant extracts i.e., Carica papaya and Embelica officinalis. These tablets were prepared by using wet granulation method. In this article the extract of leaves of Carica papaya and fruits of Embelica officinalis were used for making herbal tablets. Extracts of leaves of Carica papaya was obtained by cold extraction and through maceration method and the extract of fruits of Embelica officinalis was obtained by maceration process. Both extracts were dried and mixed. These extracts were then impregnated with the excipients like diluents, binding agents, super disintegrating agent, lubricants, etc. to make granules. These granules were then evaluated by using various parameters like Angle of repose, tapped density, bulk density, Carr’s Index, Hausner’s Ratio and void volume. These granules were then used for the making of tablets of desired size and shape by punching in the machine. After preparation of the tablets their evaluation parameters were studied like physical appearance, weight variation, friability, disintegration time, hardness test and thickness. Also the parameters for the acceptance of the tablets is also done like flavor and sweetness. Recent studies have shown that herbal extract of leaves of papaya has beneficial effect as an anti-inflammatory agent, for its wound healing properties, anti-tumor as well as Immunomodulatory effects and as an antioxidant. Amla fruit is a rich natural source of vitamin C (Ascorbic acid) and contains 600-750 mg/100 g of the fresh pulp. Also it is rich in minerals matters like phosphorus, iron and calcium. Amla is used as an Immunomodulatory agent and hence enhance the immunity of the patient. Aim of the study is to design develop and optimize the dosage form to cure dengue and is based on the use of natural plant ingredients to intermingle with chemical as well as synthetic ingredients to develop an effective unit dosage forms for better patient compliance. KEYWORDS: Papaya, Amla, Extracts, Herbal tablet, Dengue, Immunomodulatory, Platelets.