Formulation and Characterization of herbal Emulgel by using four Tradesman herb Tamarindus indica, Achyranthes aspera, Nyctanthes arbor-tristis, Syzygium cumini

Abstract

Topical drug administration is the localized administration of medication to any area of the body via the cutaneous, vaginal, ophthalmic, and rectal channels. Whether their skin is healthy or sick, they employ a wide variety of dermatological and cosmetic treatments on it. The synthesis and characterization of an herbal emulgel incorporating four traditional medicinal plants, namely Tamarindus indica, Achyranthes aspera, Nyctanthes arbor-tristis, and Syzygium cumini, are described. The emulgel formulation was prepared using a combination of natural emulsifiers and gelling agents to achieve stable emulsion and gel properties. The phytochemical analysis of the herbal extracts revealed the presence of bioactive compounds such as flavonoids, alkaloids, phenols, and tannins, known for their therapeutic effects. The emulgel was characterized for its physicochemical properties including pH, viscosity. Additionally, the emulgel was evaluated for its in vitro antioxidant activity using DPPH assay, Anti-microbial test by Escherichia coli and in vitro anti-inflammatory activity using the animal method. The results indicated that the herbal emulgel exhibited significant antioxidant and anti-inflammatory activities, attributed to the synergistic effects of the bioactive compounds present in the herbal extracts. Overall, the formulated herbal emulgel holds promise as a natural alternative for topical applications, offering antioxidant, antimicrobial and antiinflammatory benefits, which could potentially find applications in the pharmaceutical and cosmetic industries.