Abstract
The mucoadhesive drug delivery system is a drug delivery system in which drugs, along with bioadhesive polymers, are designed to contact longer in the mucous membrane of the gastrointestinal tract. This study aims to formulate glimepiride with sodium alginate polymer to produce granules in mucoadhesive form, the influence of sodium alginate on the characteristics of Glimepirid mucoadhesive granules, and the dissolution profile of Glimepiride mucoadhesive granules. The preparation is made with three formulas with various comparisons. The manufacture of granules is carried out through wet granulation. Characterization of mucoadhesive granules is performed by Scanning Electron Microscopy (SEM). Determination of levels of Glimepiride active substances and mucoadhesive granules with HPLC: ZA 99.2566%, F1 100.8666%, F2 101.01%, F3 100.8733%. The dissolution profile shows an increase in the rate of dissolution, which is 7.4013% for pure glimepiride and successive formulas FI 8.155%; FII 7.6644% and FIII 7.9942%. The mucoadhesive ability of formula III is the highest compared to other formulas, namely 96% (in vitro mucoadhesive test) and 68.67% (wash-off test). It can be concluded Glimepirid formulation with sodium alginate polymer can produce mucoadhesive preparations.
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