Abstract
Background and the purpose of the study: Development of gastroretentive delivery system is one of novel approach in oral route of drug administration. Prolonging the gastric retention time is desirable for achieving greater therapeutic benefit of drug substance. The research was aimed to develop gastroretentive mucoadhesive tablets of quetiapine for prolonged residence time. Methods: The wet granulation method was used for the preparation of various formulations (F1-F12) using different mucoadhesive polymers viz. hydroxyl propyl methyl cellulose K4M, hydroxyl propyl cellulose, chitosan, carbopol 934P and sodium carboxy methyl cellulose in different combinations. The formulations were subjected to various evaluation parameters such as swelling index, mucoadhesive strength, in vitro drug release profile and physical properties. Results: The study showed that the formulation containing chitosan and carbopol 934P in combination (F7) exhibited good swelling index, high mucoadhesive strength of 192.66 g and maximum in vitro residence time (10.14 hrs) and in vitro cumulative drug release after 24 hrs (96.26%). The optimized formulation (F7) was further subjected to in vivo retention time determination in rabbit by X-ray technique and accelerated stability studies. Conclusion: The formulation (F7) had shown promising potential to achieve desired goal as depicted from the release studies, swelling studies & mucoadhesion studies.
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