FORMULATION AND CHARACTERIZATION OF Γ-ORYZANOL LOADED SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (S-SNEDDS)

Abstract

In recent years, much attention has been paid to solid self-nanoemulsifying drug delivery systems (S-SNEDDS), which have shown reasonable successes in improving oral bioavailability of poorly soluble drugs. This drug delivery system combines the advantages of liquid SNEDDS with those of a solid dosage form and overcomes the limitations associated with liquid formulations. One optimized SNEDDS formulae F-5 were selected to be solidified by spray drying technique using Aerosil 200 as solid carrier. Characterization of GOZ Loaded S-SNEDDS by angle of repose of the one S-SNEDDS formulae F-5 were 24.12°± 1.10°, these values indicate that all formulae have good flow ability. The bulk density of the two formulae F-5 was found to be 0.47 ± 0.03 g/mL. However, tapped density was 0.57±0.02 g/mL for formula F-5. Carr’s index of formulae F-5 was found to be 13.57±1.09 which give an indication about the good flowability of the one S-SNEDDS formulae. The efficiency of self-emulsification can also be estimated by measuring the emulsification time. The emulsification time was 41.57±1.12 s. for formula F-5. The small values of PDI shown by S-SNEDDS formulae F-5 (0.403±1.12) indicate homogenous droplet population and narrow globule size distribution. The thermo gram of pure GOZ exhibited a sharp endothermic peak at about 137.25°C, corresponding to its melting point. The drug loading efficiency was found to be 96.23±0.65 for formula F-5. Within the initial one hour of the in vitro release study, only 41.02%±1.23% of GOZ was dissolved from pure drug and marketed tablets, whereas the S-SNEDDS formulae showed improved release within the same time period. GOZ dissolved and released from S-SNEDDS reached 90.02%±1.02% for formula F-5, within one hour.