Abstract
Background:Dental diseases are generally caused by oral bacteria such asEnterococcus faecalis,Streptococcus mutans, andStreptococcus sanguinis. These bacteria have resistance to synthetic drugs; thus, it is required to discover new antibacterial agents. Sarang Semut (Myrmecodia pendans) has been empirically used as a medicinal plant to treat various conditions, including those caused by pathogenic bacteria.Objective:The present study was aimed to investigate the antibacterial activity of Sarang Semut extracts againstE. faecalis,S. mutans, andS. sanguinis.Materials and Methods:Sarang Semut was extracted with several solvents to yieldn-hexane, ethyl acetate, methanol, and water extracts. Each extract and combination were adjusted for assay with chlorhexidine, fosfomycin, and quercetin and used as positive controls.Results:Then-hexane extract showed activity with inhibition zone values of 7.15 and 10.45 ppm againstE. faecalisandS. mutansat 1%, respectively. All combination extracts could inhibit the growth ofE. faecalisandS. sanguinis. The synergistic effects resulting from the combination of extract-fosfomycin were also presented in this evaluation, with the strongest shown by water-fosfomycin againstS. mutans, with inhibition zones of 28.5 mm at 1%.Conclusion:Sarang Semut extracts demonstrated antibacterial activity against oral pathogenic bacteria. These results offer alternative natural sources for the new antibacterial drug candidate.
Highlights
Oral health problems continue to be a prevalent disease of humankind, affecting all age groups [1]
All combination extracts could inhibit the growth of E. faecalis and S. sanguinis
Caries and periodontitis are associated with certain bacteria, including Streptococcus sanguinis, Streptococcus mutans, and Enterococcus faecalis, which together cause dental infection [5]
Summary
Oral health problems continue to be a prevalent disease of humankind, affecting all age groups [1]. Caries and periodontitis are associated with certain bacteria, including Streptococcus sanguinis, Streptococcus mutans, and Enterococcus faecalis, which together cause dental infection [5]. Two of these bacteria, S. mutans and S. Dental diseases are generally caused by oral bacteria such as Enterococcus faecalis, Streptococcus mutans, and Streptococcus sanguinis. These bacteria have resistance to synthetic drugs; it is required to discover new antibacterial agents. Sarang Semut (Myrmecodia pendans) has been empirically used as a medicinal plant to treat various conditions, including those caused by pathogenic bacteria
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