Formulation & development of fast dissolving film of Resperidone

Abstract

Risperidone, an Antipsychotic drugs. Risperidone undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate Fast Dissolving Film of Risperidone to overcome the limitation of bioavailability and increase patient’s compliance. In the present study Fast Dissolving Film were prepared by solvent-casting method using hydrophilic polymer HPMC K4M and PEG 400 as plasticizer. The eighteen formulations were prepared by the application of heat drying technique and evaluated for the fast dissolving films specification and characteristics. It was found that, the films has potential to modify drug release rate and possess good stability and less fragile property. The F9 batch of dried Fast Dissolving Film has shown promising drug release within 10 min (95.11%) and tensile strength.