Formulation & Development of Baclofen microemulsion incorporated into Transdermal patch

Abstract

The current study aims at developing formulations based on microemulsions for the transdermal patch of Baclofen. Castor oil was used in the oil phase, Tween-20 was used as a surfactant, propylene glycol(PG) worked as a cosurfactant, and water worked as an aqueous phase in the formation of microemulsions. Using Franz diffusion cells, in vitro permeation tests were conducted. At the conclusion of 8 hours, the in vitro permeation release of ME-3 was determined to be 88.79%, and baclofen microemulsion was later put into the transdermal patch. The most effective composition was ME-3, which included dimethyl sulfoxide as a penetration enhancer, propylene glycol as a plasticizer, and carbopol 940 as a bio-adhesive polymer. The formulation with the best penetration enhancement exhibited a 39-fold increase and contained 0.1% DMSO. It was discovered that ME-3 Patch has a 97.67% in vitro permeation release rate. According to a study, baclofen may be produced into transdermal patches with an acceptable appearance and an appropriate drug release time of 4 hours.
 Keywords: (ME-)Microemulsion, HPMC, Transdermal patch, Baclofen, Carbopol- 940