Formulating extended-release Meloxicam Pellets using the membrane coating technique

Abstract

Background: Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic effects but is associated with various side effects such as inducing gastrointestinal ulcers. Extended-release meloxicam pellets offer several advantages, including reducing the frequency of daily medication intake and providing sustained drug release over time, thereby minimizing gastrointestinal side effects. The study was conducted to formulate and develop the manufacturing process for meloxicam pellets, while simultaneously evaluating the physicochemical properties of the formulated pellets. Materials and methods: Meloxicam, HPMC E5, and Ethyl Cellulose N7 were used in the study. Meloxicam pellets were formulated using the layering technique, initially depositing the drug onto inert pellets and subsequently extending the coating with Ethyl Cellulose N7. Results: The pellet formula utilizes EC N7 with the role of providing extended-release kinetics following zero-order kinetics. The pellets exhibit uniform and attractive appearance, with dimensions ranging from 0.7 - 1 mm. The drug content is 2.38% ± 0.11% (w/w), demonstrating the ability to release the drug according to a zero-order kinetic model. Conclusions: The study successfully formulated extended-release meloxicam pellets using a coating technique that involved a gradual deposition phase of the drug onto inert pellets, followed by an extended coating phase using a controlled-release excipient. Key words: Meloxicam, pellet, coating technology.