Abstract
Red cabbage flower (Brassica oleracea L.) contains antioxidant compounds with strong activity potential. This research aims to make antioxidant gel preparations using HPMC as a base gel containing red cabbage flower extract with concentrations (% b/b) for F1, F2 and F3 are 5%, 7,5% and 10%, which are then evaluated and tested its antioxidant activities. Testing antioxidant activity is carried out by the determination method of IC50 using the reagent DPPH (Difenil-2-Pikrilhidrazil). From research acquired the value of IC50 for ethanol extract red cabbage flower and vitamin c as comparative compounds is 47,10 ppm and 6,30 ppm. Antioxidant activity of red cabbage flower ethanol extract in gel preparations in each formulation has a IC50 value of 80,15 ppm (F1), 59,71 ppm (F2), and 57,48 ppm (F3). Evaluation ofgel preparation includes homogenity, organoleptic, viscosity and pH. The physical properties test results of gel dosage showed that all the preparations of the homogeneous gel, have a pH between the 5,30-5,70 corresponding to the skin pH, with a viscosity value of 3000-3700 cps, and have a coverage of ≤ 7 cm. Based on the results of this study, it was concluded that red cabbage flower ethanol extract can be formulated in an antioxidant gel with the best concentration is 10%.
Highlights
Red cabbage flower (Brassica oleracea L.) contains antioxidant compounds with strong activity potential
make antioxidant gel preparations using HPMC as a base gel containing red cabbage flower extract with concentrations
From research acquired the value of IC50 for ethanol extract red cabbage flower and vitamin c
Summary
Program Studi Farmasi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor 3. Mahasiswa Program Studi S1 Farmasi Sekolah Tinggi Teknologi Industri dan Farmasi Bogor. Penelitian ini bertujuan untuk membuat sediaan gel antioksidan dengan menggunakan HPMC sebagai basis gel yang mengandung ekstrak etanol bunga kubis merah dengan konsentrasi (% b/b) untuk F1, F2 dan F3 adalah 5%, 7,5% dan 10%, yang kemudian dievaluasi dan diuji aktivitas antioksidannya. Hasil uji sifat fisik sediaan gel menunjukkan bahwa semua sediaan gel homogen, memiliki pH antara 5,30-5,70 yang sesuai dengan pH kulit, dengan nilai viskositas 3000-3700 cps, dan memiliki daya sebar ≤ 7 cm. Berdasarkan hasil penelitian ini, disimpulkan bahwa ekstrak etanol bunga kubis merah dapat diformulasikan dalam sediaan gel antioksidan dengan konsentrasi terbaik adalah 10%
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