Abstract
Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia. Isolated extracts and metabolites of Z. zerumbet have shown anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial, analgesic and antiviral activity. The form of suspension is carried out to facilitate the utilization of the main bioactive content, zerumbone, which is difficult to dissolve in water. The formulation of suspension is based on variations in the concentration of Z. zerumbet extract, which is 2.5% (formulation 1), 5% (formulation 2), and 10% (formulation 3). To determine the physical stability, the evaluation is carried out, namely: organoleptic test, density, viscosity, redispersibility and pH. The results showed all three formulations did not provide organoleptic changes for 30 days, >1 g/cm3 density, good redispersibility, and pH of 6. The viscosity of each formulation is quite varied i.e., 3.74 cp; 4,27 cp; and 11.8 cp. Formulation 3 is determined as the best formulation based on its viscosity which is closest to the standard range of good suspension viscosity according to the SNI.
Highlights
Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia
The results showed all three formulations did not provide organoleptic changes for 30 days, >1 g/cm[3] density, good redispersibility, and pH of 6
Diperlukan penambahan pemanis yang lebih banyak untuk mengurangi rasa pahit dari ekstrak lempuyang gajah
Summary
Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia. Hasil stabilitas suspensi menunjukkan ketiga formulasi tidak memberikan perubahan organoleptis selama 30 hari, massa jenis >1 g/cm[3], redispersibiltas yang baik, dan pH 6. Sediaan hasil ekstraksi lempuyang gajah (Zingiber zerumbet (L) Smith) yang dilakukan dengan metode Ultrasound-Assisted Exctraction (UAE) akan dibuat dalam bentuk suspensi agar mudah dimanfaatkan tanpa mengurangi aktivitas farmakologisnya. Penelitian pengembangan formulasi sediaan suspensi ekstrak Zingiber zerumbet ini juga dapat mewujudkan saran dari Kementerian Kesehatan untuk pemanfaatan obat tradisional sebagai upaya pemeliharaan kesehatan dan pencegahan penyakit[10].
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