Formulasi dan Penentuan Orde Pelepasan Teofilin Sediaan Granul Campuran Kitosan dengan Metilselulosa

Abstract

The in vitro study was carried out on the release of active ingradient theophylline from granules prepared by moist granulation method. The granule matrix was prepared from the mixture of chitosan isolated from SwaIIo shrimp (Metapenaeus monoceros) (in accordance with the Protan Laboratories, Inc standard requirement) and methylceliuiose 1500 cps. The granules were filled into 1000 mg capsules containing 200 mg theophylline. The result showed that, when the amount of chitosan was kept constant, an increase in the amount of methylcellulose will increase the release rate of theophylline from granules. And theophylline release kinetics from chitosan granules or a mixture of chitosan methylcellulose does not provide zero-order. The results provide information that the kinetics of drug release followed first order and Higuchi.