Abstract
The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.
Highlights
The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity
The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets
Optimasi Formula Sediaan Tablet Ekstrak Daun Salam Sebagai
Summary
Alat yang digunakan adalah gelas-gelas kimia, blender, penguap vakum putar (rotary. evaporator), magnetic sirrer, satu set alat homogenizer (WiseTis), satu set alat sentrifuse (K Sentrifuse PLC series), freezer dan air cooler, satu set alat pengering. Sebanyak 1 ml larutan uji ditetesi larutan NaOH, didiamkan beberapa saat dan hasil positif ditunjukkan adanya warna kuning (Tirza Lang, 2014). Sebanyak 1 ml larutan uji ditetesi larutan Gelatin dan adanya endapan menunjukkan hasil positif (Tirza Lang, 2014). Sebanyak 1 ml larutan uji lalu ditetesi larutan dragendroff, didiamkan beberapa saat dan hasil positif terdapat noda jingga (Tirza Lang, 2014). Sebanyak 1 ml larutan uji dikocok kuat, didiamkan beberapa saat, hasil positif ditunjukkan dengan adanya busa (Tirza Lang, 2014). Sebanyak 1 ml larutan uji ditetesi larutan pereaksi Lieberman Burchard, didiamkan beberapa saat dan hasil positif ditunjukkan dengan warna merah coklat (Tirza Lang, 2014). Pembuatan Granul Nanopartikel Ekstrak Daun Salam (Syzygium polyanthum). Larutan nanopartikel yang sudah diukur dengan PSA kemudian dipisahkan dengan menggunakan sentrifugasi. Timbang serbuk nanopartikel ekstrak daun salam, na alginat, avicel PH 102, sodium
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