Abstract
Methylamphetamine, chlorpromazine, phencyclidine and imipramine were administered in the drinking water of rats during pregnancy and the suckling period. Male offspring were given no drugs after weaning until nine months later; groups were then injected with p-chlorophenylalanine or saline, killed nine hours later and the brains dissected into eight areas. Exposure to methylamphetamine, chlorpromazine or phencyclidine during the period of brain development was found to have had permanent effects both on 5-hydroxytryptamine concentrations and on the rate of depletion after synthesis blockade.
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