Abstract
The effectiveness of ring A reduced (5α and 5β) testosterone (T) derivatives upon the rat uterus spontaneous contractility was tested in vitro . Compounds with the 3α-hydroxy-5α reduced configuration, such as androsterone and androstanediol, and one 5β reduced (5β-dihydrotestosterone) elicited a remarkable inhibitory effect upon the myometrial activity. Although steroids with 5β reduction were less potent than 3α-hydroxy-5α reduced compounds for depressing the myometrial activity, they were somewhat more potent than T, DHEA, androstenedione and the remaining 5α reduced compounds tested. Therefore, T could act as a “prehormone”, accounting for the maintenance of the physiological myometrial activity through its 5-reduced derivatives.
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