Abstract
D 1 D 2 interaction in rat striatum was investigated by examining the effect of the D 2 antagonist spiperone on the binding of [ 3H]SCH23390 to D 1 dopamine (DA) receptors. In the presence of endogenous DA, spiperone blocked D 2 receptors, then caused the increase of the binding of [ 3H]SCH23390 in rat striatal homogenate. After the 6-hydroxydopamine (6-OHDA) lesion, the increase was not found even if in the addition of exogenous DA. The results suggest that the D 2 antagonist can modify the interaction between endogenous DA and D 1 receptors labeled with [ 3H]SCH23390, while 6-OHDA lesion may change the state of D 1 D 2 interaction operating at the receptor level.
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