Abstract
PURPOSE: The development of cancer cachexia is the most common manifestation of advanced malignant disease. METHOD: The effects on muscle regeneration of β2�adrenoceptor agonist formoterol (0.3 mg/kg) were tested in cachectic tumourbearing rats (Yoshida AH�130 ascit es hepatoma). RESULTS: Administration of formoterol results in a significant increase in the mass and protein content of tibialis muscle in tumourbearin grats. This increase is associated with a decreased myogenin mRNA content together with an increased Pax�7 gene expression. Bupivacaine treatment by local injection results in an important reduction in tibialis weight together with significant increases in Pax�7, myogenin and MyoD gene expression. Formoterol treatment in bupivacainetreated rats results in significant increases in Pax�7 together with significant decreases in myogenin mRNA content, suggesting that this β2�agonist is favouring muscle regeneration by stimulating the proliferation of satellite cells. Altogether, the data reinforce the potential role of formoterol in the treatment of muscle wasting diseases.
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