Abstract
Hemolytic disease of the newborn is a clinical situation in which fetal red blood cells are destroyed by maternal IgG-type alloantibodies directed against paternal antigens. Unlike fetal-maternal alloimmunization in the RHD system, which leads to severe hemolytic disease, fetal-maternal alloimmunization in the ABO system generally results in benign hemolysis. We present a retrospective study of eight cases of severe ABO, collected over a 5-year period from January 2016 to December 2022. All the mothers were O+ grouped with negative RAI. Severity criteria were early jaundice, positive Coombs test and severe hemolysis with profound anemia.
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