Abstract
ABSTRACTDiacetylenic phospholipid dispersions in water produce tubules (500 nm diameter) and helices from their initial vesicular morphology as a function of temperature and concentration. A binary mixture consisting of diacetylenic phospholipid, 1, 2 bis (tricosa-10, 12-diynoyl)-sn-glycero-3-phosphocholine and a short chain phospholipid, 1, 2-dinonanoyl -sn-glycero-3-phosphocholine was studied to explore the morphological transformation of lipids into tubules to develop an approach to control and produce tubules of different diameters. Circular dichroic spectra not only indicated the chiral nature of these tubules, but also provided distinct spectral signatures differentiating micro- and nanotubules. The effects of temperature and lipid concentration on the formation and stability of tubules were also explored. An equimolar lipid mixture provided structures with uniform morphology, which were stable for several hours up to 36 °C. The thermal stability of nanotubules makes them an attractive candidate for many practical applications including controlled release technology.
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