Formation of specific immunity in piglets during vaccination against circovirus infection

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The article presents the results of studying the formation of specific immunity in piglets during vaccination against circovirus infection. Circovirus diseases of pigs, manifested by the defeat of many body systems, are widespread and cause great economic damage in industrial pig farms. The study of the formation of specific immunity during vaccination of piglets against circovirus infection is of scientific and practical interest. The purpose of the research is to study the formation of specific immunity in piglets during vaccination against circovirus infection. It was found that vaccination is accompanied by activation of the innate immunity system, which initiated the launch and formation of an antigen-specific adaptive immune response. In animals 6 days after the introduction of the vaccine, compared with intact piglets, an increase in the content of pro-inflammatory cytokines IL-1ß, TNF-α, IFN-α and IFN-γ and the anti-inflammatory mediator IL-4 was found, indicating a cellular and humoral immune response. An increase in the indices of inflammatory activity of mediators and the ratio of pro- and anti-inflammatory cytokines indicates an increase in the activity of T-helper I and the prevalence of cellular immune response. Under the influence of technological stress caused by weaning from sows and transfer to rearing, animals 14 days after vaccination showed a decrease in the level of IL-2, IFN-α and IFN-γ, inducing cellular immunity, as well as cytokine index, the ratio of pro- and anti-inflammatory mediators, which indicates a shift in the direction of the immune response in the side of activation of the functioning of T-helper II, indicating the predominant formation of humoral immunity.