Abstract
Summary Hypothermia, induced in rats, caused marked disaggregation of brain polysomes. The disaggregation was reflected primarily as an increase in the dimer peak and was accompanied by a reduced capacity for amino acid incorporation in vitro , by post-mitochondrial fractions. The disaggregation ,as well as the changes in amino acid incorporation ability caused by hypothermia, were reversible, inasmuch as brains of hypothermic rats brought back to normal temperatures before sacrifice had polysome profiles similar to those of control animals. The changes in polysome patterns due to hypothermia could not be observed if the animals were treated with cycloheximide before induction of hypothermia.
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