Abstract

A one-pot single-step novel process has been developed to form microbubbles up to 250 μm in diameter using a pressurized rotating device. The microbubble diameter is shown to be a function of rotational speed and working pressure of the processing system, and a modified Rayleigh-Plesset equation has been derived to explain the bubble-forming mechanism. A parametric plot is constructed to identify a rotating speed and working pressure regime, which allows for continuous bubbling. Bare protein (lysozyme) microbubbles generated in this way exhibit a morphological change, resulting in microcapsules over a period of time. Microbubbles prepared with gold nanoparticles at the bubble surface showed greater stability over a time period and retained the same morphology. The functionalization of microbubbles with gold nanoparticles also rendered optical tunability and has promising applications in imaging, biosensing, and diagnostics.

Highlights

  • Microbubbles are an interesting and promising class of materials consisting of a spherical core−shell structure and provide a unique platform for various applications

  • We investigate the sorption of gold nanoparticles onto the bubbles as a means of both influencing physical stability and expanding the range of therapeutic applications of these novel systems

  • The measured values of surface tension were 67, 65, 62, and 60 mN m−1, and the measured values of viscosity were 3079, 360, 330, and 306 mPa s for poly(vinyl alcohol) (PVA)−lysozyme and gold nanoparticle containing lysozyme solutions with a ratio of 1:10, 1:5, and 2:5 (v/v), respectively

Read more

Summary

Introduction

Microbubbles are an interesting and promising class of materials consisting of a spherical core−shell structure and provide a unique platform for various applications. They have been shown to improve the desired properties in food systems, including texture, digestibility, and flavor intensity.[11,12]

Methods
Results
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.