Abstract
Testicular extracts from rats treated with 500 r of total-body x irradiation exhibited changes in rates of phosphate ester formation when incubated with inorganic phosphate in the presence of adenosine or guanosine. These changes were noted 24, 72, and 168 hours after irradiation, and they represent extended effects of sublethal x radiation: immediate effects, 30 and 120 minutes postirradiation, were also observed. Some esters were formed at increased rates 24 hours afte r radiation, particularly when testicular extracts were incubated with guanosine, and subsequent changes in rates were also greater with this substrate. Immediately after radiation rates of phosphate esterification were decreased in presence of either nucleoside. With guanosine the decrease in rates was greater than with adenosine. These rate studies of phosphate esterification by testicular extracts showed that sublethal effects of x rays on enzymatic systems can be detected shortly after irradiation or after extended postirradiation intervals. (auth)
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