Abstract
The impurities in penicillins such as proteins and polymers have been investigated’ -j and the chemical aspects of penicillins have been studied4 -7. Penicillins form polymers by cleavage of the /J-lactam in aqueous solutions at room temperature, and these polymers are considered to be one of the causes of penicillin allergya1’. For the study of penicillin polymer formation, Sephadex G-25 chromatography has been widely used. We, however, found strong adsorption of a few penicillins to the gel and the peaks of penicilloic acids formed by cleavage of the p-laa Sephadex LH-60 was used and a chromatographic system was designed for molecular weight determinations. This paper describes the formation of polymers of ampicillin, amoxicillin, piperacillin and PL-385 (Fig. l), and the determination of the molecular weights of the polymers by using Sephadex LH-60.
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