Abstract
Okazaki's model of discontinuous DNA synthesis, supported by the discovery of nascent DNA fragments at the replication fork (Okazaki pieces), provided a solution to the problem of how antiparallel DNA strands could be simultaneously replicated (Okazaki et al. 1969). Since Okazaki's initial observations, many investigators have shown that in a wide variety of biological systems nascent DNA at the replication fork is found in the form of Okazaki pieces which must be sealed to give normal-length mature DNA.
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