Abstract
The DNA methylating activities of N-nitrosodimethylamine (NDMA), an initiator of hepatic gamma-glutamyltranspeptidase-positive foci, and N-nitrosomethylbenzylamine (NMBzA), which does not initiate, were studied in regenerating rat liver. Equimolar doses of 14C-labelled NDMA and NMBzA (33.5 mumol/kg) were administered to male Sprague-Dawley rats 18 h after partial hepatectomy. NDMA and NMBzA both produced 7-methylguanine and O6-methylguanine. The results suggest that although the formation of O6-methylguanine may be necessary it is not sufficient for initiation of preneoplastic foci.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
