Abstract
Langmuir monolayers of diacetylene lipids with a cytosinyl head-group (PDC), mixed withan alcohol derivative of the same lipid (PDOH), were formed on water and on guanosinesolution, and were UV polymerized in situ. Brewster angle microscopy (BAM),atomic force microscopy (AFM) and visible light absorption spectroscopy wereperformed on the monolayers. It was found that the optimal ratio for the lipidmixtures is approximately 2:1 PDC/PDOH. For lipid mixtures with differentratios, the film decomposes into phases of the preferred composition and a secondphase enriched with the excess compound. The stable mixed phase exhibits adistinct striated appearance along the polymer linear direction. Films formed onguanosine-containing subphase have similar phases; however, the stable striated phaseappears more developed in the direction perpendicular to the polymer chains. Aspecific base-pair formation at the air–solution interface between the diacetylenemonolayer and the free complementary nucleoside in the solution is suggested.
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