Formation of N−P(O)−S Bonds from White Phosphorus via a Four‐Component Reaction

Abstract

AbstractFunctionalization of white phosphorus with disulfides, amines and KOH to phosphoramidodithioates containing both P−N, P−S and P=O bonds via a four‐component reaction is presented. It proceeds with high yields and provides an attractive approach for the construction of valuable N−P(O)−S motif using a one‐step strategy. The advantages of this newly developed process include a clean reaction profile, complete conversion of white phosphorus, transition metal‐free and halogen‐free environmentally benign system, and large‐scale synthetic application. Besides, phosphoramidodithioates can also be utilized to construct P−C, P−O and P=S bonds with the appropriate reagents.magnified image