Abstract
1. 1. It has been confirmed that the oxidation of GSH by linoleic acid hydroperoxide is enzymically catalyzed in rat liver. 2. 2. By thin-layer chromatography, gas-liquid chromatography and mass spectrometry, and by chemical modifications such as acetylation, methylation and hydrogenation, the products formed by the enzymic removal of linoleic acid hydroperoxide have been identified as 9-hydroxy-10,12-octadecadienoic acid and 13-hydroxy-9,11-octadecadienoic acid. The hydroperoxide can thus be detoxified to products that can be metabolized in the cell. 3. 3. It is suggested that the extremely rapid enzymic reaction of GSH with lipid hydroperoxides breaks the autocatalytic chain reactions of lipid peroxidation and thus protects the vital cellular compounds from the effect of lipid peroxides.
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