Abstract
We report an efficient approach for the fabrication of hydrophobic drug-loaded human serum albumin nanofibers for the first time. The successful formation of nanofibers was found closely related to the glutathione (GSH) concentration, solution temperature, and heating time. As-fabricated nanofibers were characterized by electron microscopy, Fourier transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). The electron micrographs show that nanofibers have cylindrical morphology and diameters of 70–120nm and lengths of up to few micrometers with a smooth surface. GSH was found to contribute to the quicker unfolding of the HSA under high temperature (80–85°C) which resulted in the strong interaction with paclitaxel, leading to a morphological transformation from nanoparticles to nanofibers. In addition, the possible mechanisms of nanofiber formation have been discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
