Abstract
Muscarinic receptor subtype in type-1 and type-2 astrocytes from rat neonalal cerebral cortex was examined for carbachol-elicited inositol phosphate (IP) formation. The formation of carbachol-elicited IP was inhibited by various muscarinic antagonists in the following relative order of potency: 4- DAMP ≧ atropine ⪢ pirenzepine > AF-DX 116 . This pharmacological profile suggests that the activation of the M 3 muscarinic receptor subtype is responsible for the stimulation of IP formation in both astrocytes.
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