Abstract
The purpose of this study is to examine the possible use of rice glycosphingolipids (RGSLs) as an emulsifier to form food grade microemulsions (mean particle size, 10–20 nm) and improve the absorption of CoQ10 with a poor solubility property by prepared emulsion. Because RGSLs could act as an auxiliary emulsifying agent, its addition to the surfactant/oil mixture decreased the emulsion’s particle size. This suggests that RGSLs exist between the water and oil phases to decrease oil droplet size via reduced interfacial tension. CoQ10-loaded microemulsion was also successfully prepared with RGSLs and powdered after freeze-drying with a cryoprotectant. CoQ10’s solubility in freeze-dried particles was dramatically improved compared to that of CoQ10 powder. Moreover, oral absorption of CoQ10 was significantly enhanced when administered via CoQ10-loaded microemulsion. The area under the plasma concentration–time curve for the microemulsion improved up to seven-fold compared to CoQ10 powder. The use of RGSLs could, therefore, be an effective processing technique for improving CoQ10’s solubility and absorption.
Highlights
Coenzyme Q10 (CoQ10), existing in the inside of the inner mitochondrial membrane, functions as the production source of cellular energy and adenosine triphosphate. [1]
When CoQ10-loaded microemulsion was the emulsion was stable without phase separation because a change in particle size and encapsulation stored for 4 weeks at 37 °C, the emulsion was stable without phase separation because a change in efficiency did not occur compared to the product immediately after preparation
rice glycosphingolipids (RGSLs) can assist in emulsifying the formulation consisting of polysorbate 80 and TG
Summary
Coenzyme Q10 (CoQ10), existing in the inside of the inner mitochondrial membrane, functions as the production source of cellular energy and adenosine triphosphate. [1]. Emulsions exhibiting a particle size less than 200 nm can be prepared by spontaneous emulsification without the use of an emulsifying apparatus [13,14]. Reported that a nanoemulsion less than 100 nm, including ω-3 fatty acids, can be prepared using a spontaneous emulsification method [15]. Lipid mixtures with higher hydrophilic-lipophilic nano-sized emulsion depending onco-surfactants their component ratios. Surfactants, oils, and/or lead to the formation of nano-sized emulsion tocopherolpolyethylene glycol succinate, a non-ionic emulsifier, have been examined as high depending on their component ratios. GSLs oil-based formulation because of their low solubility in water or oil alone. Rice glycosphingolipids (RGSLs) were investigated as as additive to prepare a nano-sized emulsion containing. Polysorbate 80 and Caprylic/capric triglyceride (TG) were used as a surfactant and oil, prepared emulsion. CoQ10 to rats. in a CoQ10-loaded emulsion were compared to those of untreated CoQ10 powder after oral administration to rats
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
