Abstract
The induction and repair of DNA double-strand breaks in hippocampal formation after exposure to accelerated 78Kr ions with an energy of 2.58 GeV/nucleon has been studied using the immunohistochemical staining of rat-brain paraffin sections with antibodies specific to γH2AX and 53BP1 proteins. Following exposure to heavy ions, complex clusters of double-strand breaks are detected in various structures of hippocampal formation. It is shown that most γH2AX/53BP1 foci are part of complex clusters (~80%) and colocalized with visualized repair proteins (~75%) along the tracks of heavy charged particles. After 24 h of postirradiation incubation, the effective elimination of radiation-induced γH2AX/53BP1 foci is observed in the cells of the dentate gyrus and the CA1 region of the hippocampal formation. In the cells of the dentate gyrus, the peak of γH2AX/53BP1 formation occurs 4 h after irradiation.
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