Abstract
We report synthesis of dimers composed of a single short double-stranded(ds)DNA molecule connecting two gold nanoparticles (GNPs). Such struc-tures may be useful for electrical transport measurements through dsDNAmolecules and for other research purposes. When the DNA molecules areshort with respect to the size of the GNP, gel electrophoresis cannot separ-ate GNPs with different numbers of DNA molecules attached to them. Wepresent two methods to separate GNPs connected to single short thiolatedsingle-stranded (ss)DNA. The separation is performed by hybridizing theDNA/GNP conjugates with long, partially complementary, ssDNA or withcomplementary ssDNA connected to GNPs of smaller size. The separatedGNPs with a single short ssDNA were used to form dimers consisting ofGNPs connected by a single short dsDNA molecule.
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