Abstract
The complexation of deoxyribonucleic acid (DNA) with Cu(II) and other bivalent metal ions was studied at relatively low molar ratios of the metal ion to phosphoric acid residues (HL) of DNA (TM2+/THL) by potentiometry, ultraviolet, visible, infrared and circular dichroism spectrophotometry, and electron spin resonance spectroscopy. A Cu(II) ion forms a stable complex with DNA in the pH region above 7.3. In the pH region from 4 to 10, various bivalent metal ions can form complexes with DNA, the complexation ability being in the order of Cu(II)>Zn(II)>Co(II)>Ni(II)\\simeqMg(II). When TCu2+/THL is lower than 0.33, the structure of DNA (B-form) does not change by such complexation. Cu(II) ions are coordinated mainly with the phosphoric acid residues of the same DNA chain. However, this coordination bond is relatively weak.
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